The Effect of Sodium Alginate on Physical and Dissolution Properties of Surelease^[○!R]-Matrix Pellets Prepared by a Novel Pelletizer

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概要

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• The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease^[○!R]-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (e_R) and the aspect ratio of Surelease^[○!R]-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease^[○!R]-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release rate than the drug release mechanism within the Surelease^[○!R]-matrix for sparingly water-soluble drug, such as tamsulosin hydrochloride.

• 公益社団法人日本薬学会の論文
• 2007-11-01

著者

• KIM Jeong-Soo

  National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National Universi

• KIM Min-Soo

  National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National Universi

• HWANG Sung-Joo

  National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National Universi

• Kim Min-Soo

  National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National University

• Kim Jeong-Soo

  National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National University

関連論文

• Statistical Optimization of Tamsulosin Hydrochloride Controlled Release Pellets Coated with the Blend of HPMCP and HPMC
• The Effect of Sodium Alginate on Physical and Dissolution Properties of Surelease^[○!R]-Matrix Pellets Prepared by a Novel Pelletizer

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