Tumor Angiogenesis in Lung Adenocarcinomas : Correlation with FDG Uptake and Prognosis
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PURPOSE To investigate correlation of angiogenic factors (VEGF, Angiopoietin-2) expression and hypoxia inducible factors (HIF-1α, HIF-2α) expression with FDG uptake and prognosis in lung adenocarcinomas. MATERIALS AND METHODS Forty-four patients with forty-five lung adenocarcinomas were performed FDG PET before surgery. FDG-PET measurements were performed 40 minutes after intravenous injection of approximately 185 MBq FDG on a dedicated PET scanner. Consecutive paraffin-embedded sections obtained from each resected tumor were immunostained for VEGF, Angipoietin-2, HIF-1α, HIF-2α and Glut-1, respectively. The Kaplan-Meier survival method was used to calculate survival rates, and the log-rank test was used to compare groups with respect to survival. RESULTS FDG uptake significantly correlated with VEGF (P=0.05) and Angiopoietin-2 (P=0.003) expression ; higher FDG uptake usually means higher VEGF and Angiopoietin-2 expression. While HIF-1α expression had no significant correlation with FDG uptake, HIF-2α expression had a significant correlation with FDG uptake (P=0.009) and Glut-1 expression (P=0.004). The patients with SUV#5 (P=0.00001), low VEGF (P=0.006), low Angiopoietin-2 (P=0.0002), low HIF-1α (P=0.04) or low HIF-2α (P=0.0001) expression had a significantly better disease-free survival probabilities than the others. CONCLUSION Angiogenic factors (VEGF, Angiopoietin-2) expression and HIF-2α expression significantly correlated with FDG uptake and prognosis in lung adenocarcinomas. This may have applications in assessing and monitoring antiangiogenic therapy.
- 金沢医科大学の論文
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