肝切除後のトリプシンインヒビターとサイトカインの血液中の動態に関する研究

概要

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The excretion of urinary trypsin inhibitor (UTI) in urine is known to increase when the body is invaded, but the physiological activity and directly-related dynamics of UTI in blood, as well as its physiological significance, remain unclear. UTI levels was able to measure in blood pretreated with perchloric acid, and we serially investigated UTI concentration in blood of subjects before and after hepatectomy. At the same time, we measured serum levels of cytokines (interleukin-6, interleukin-8, hepatocyte growth factor) and investigated their relation with UTI. Blood UTI concentration decreased immediately following hepatectomy, after which it increased. The degree of increase was lower in patients with decreased hepatic function and in those who had a resection of major part of their liver. Similarly, the postoperative increase in blood UTI concentration appeared to be inhibited in the highly elevated group of cytokines. The present findings suggest it may be possible to predict which patients will need preventive administration of UTI to avoid liver failure in the perioperative period by measuring UTI and cytokine levels in blood.
愛知医科大学の論文
2006-03-15