THIRTEEN-WEEK REPEATED DOSE ORAL TOXICITY STUDY OF COENZYME Q_<10> IN RATS

概要

論文の詳細を見る
As part of a safety evaluation of Coenzyme Q_<10>, a subchronic toxicology study was conducted. Coenzyme Q_<10> was repeatedly administered orally to male and female Crl:CD(SD) rats at daily dose levels of 300, 600 and 1200mg/kg for 13 weeks. Neither death nor any toxicological signs were observed in any group during the administration period. No change related to the test substance administered was observed in any group with regard to body weight, food consumption, ophthalmoscopy, hematology, blood biochemistry, necropsy, organ weights or histopathology. Based on these results, the non-observed-adverse-effect level (NOAEL) of Coenzyme Q_<10> was considered to be 1200mg/kg/day for male and female rats under these study conditions.
日本トキシコロジー学会の論文
2007-10-15