TOXICITY SCREENING AFTER REPEATED DOSE OF A NEWLY DEVELOPED ORAL HEPARIN DERIVATIVE IN MALE CYNOMOLGUS MONKEYS

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概要

• 論文の詳細を見る

• Toxicity screening of a newly developed oral heparin derivative was carried out in twelve male cynomolgus monkeys (Macaca fascicularis), composed of three treatment and vehicle control groups. A newly orally active heparin derivative, developed by Seoul National University, was given to the treatment group at three doses with low (12.8mg/kg), medium (89.6mg/kg) and high (640mg/kg) doses for 14 days. A treatment group did not show any change in body weights, hematological parmeters (e.g., RBC, WBC, platelet, PDW, MPV, etc.) and serum biochemical parameters (e.g., AST, ALT, BUN, etc.) for 2 weeks compared with those of the vehicle control group. These findings indicated that the oral anticoagulant drug, a newly developed oral heparin derivative, did not have any toxic effect for 2 week in this study. The present study will be valuable in the proper interpretation for non-clinical study using cynomolgus monkeys in the development of a new drug of heparin derivative.

• 2007-10-15

著者

• Kim Choong-Yong

  Non-human Primate Team, Toxicology Division, Korea Institute of Toxicology

• Kim Choong-yong

  Non-human Primate Team Toxicology Division Korea Institute Of Toxicology

• Byun Youngro

  College Of Pharmacy Seoul National University

• KIM JeeEun

  Non-human primate team, Toxicology Division, Korea Institute of Toxicology

• HAN KangHyun

  Non-human primate team, Toxicology Division, Korea Institute of Toxicology

• KIM SangKyoon

  Department of materials science and engineering, Gwangju Insititute of Science and Technology

• PARK KuiLea

  National Institute of Toxicological Research

• Kim Jeeeun

  Non-human Primate Team Toxicology Division Korea Institute Of Toxicology

• Han Kanghyun

  Non-human Primate Team Toxicology Division Korea Institute Of Toxicology

• Kim Sangkyoon

  Department Of Materials Science And Engineering Gwangju Insititute Of Science And Technology

関連論文

• TOXICITY SCREENING AFTER REPEATED DOSE OF A NEWLY DEVELOPED ORAL HEPARIN DERIVATIVE IN MALE CYNOMOLGUS MONKEYS
• Changes of Blood Parameters after Escalating dose with DA-3021 in Cynomolgus Monkey (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)

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