Middle Ear Carcinoid Tumor : Case Report and Literature Review

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We herein report a rare case of a carcinoid tumor observed in the middle ear. The 51-year-old female patient presented to our hospital with an 8-year history of mild deafness and sensation of obstruction within the left ear. Otoscopic examination revealed a pinkish mass in the hypotympanum, which was visible through an intact tympanic membrane. Computed tomography (CT) of the temporal bone showed a well-circumscribed mass of soft tissue density filling the left hypotympanum. The provisional clinical diagnosis was cholesteatoma or another type of tumor (e.g. glomus jugulare tumor or facial nerve neurilemmoma). Transcanal tympanotomy was performed under general anesthesia to explore the lesion. At surgery, a well-delineated, encapsulated pinkish mass was found in the hypotympanum. It was not adherent to the tympanic membrane or ossicles. The mass arose, via a narrow pedicle, from the lining epithelium at the promontory. Complete resection of the mass was performed with careful clearance around the ossicles and epithelium at the promontory. Histological examination showed a carcinoid tumor composed of islands, cords, and nests of tumor cells in a fibrous stroma. Immunohistochemistry revealed granular cytoplasmic positivity for chromogranin A. No general symptoms of carcinoid syndrome were observed in this patient. Endoscopic examination revealed no evidence of other carcinoid tumors in the gastrointestinal and respiratory tracts. Eight years postoperatively, no evidence of recurrence or metastatic disease has been observed.
獨協医科大学の論文
2006-07-25

Middle Ear Carcinoid Tumor : Case Report and Literature Review

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