The Effects of Olprinone Hydrochloride on Hemodynamics : Status in Patients with Moderate and Severe Preoperative Cardiac Function Under Cardiac Surgery

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概要

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• We compared the effects of olprinone hydrochloride in 22 patients undergoing coronary artery bypass grafting, to compare effectiveness and the relationship to hemodynamics. Patients were divided into 2 groups : Group M, with moderate preoperative cardiac function (Left ventricular ejection fraction 45% and cardiac index >2.5;n=10) ; and Group S, with severe (Left ventricular ejection fraction <__-45% and cardiac index <__-2.5;n=12) preoperative cardiac function. At time of weaning from cardiopulmonary bypass, both groups were administered 15μg/kg olprinone hydrochloride as a bolus, then 0.1μg/kg/min olprinone hydrochloride was infused continuously. In both groups, olprinone significantly increased cardiac index and stroke volume index. Rate of increase in cardiac index and stroke volume index after administration of olprinone was higher for Group S than that of Group M for an extended period of time. Ratio of increase in heart rate was significantly lower for Group S than that of M group. Thus, olprinone hydrochloride can effectively improve hemodynamics after emergence from cardiac bypass in cardiac surgical patients with severe preoperative cardiac function.

• 獨協医科大学の論文
• 2006-07-25

著者

• Okuda Yasuhisa

  Department Of Anesthesiology Dokkyo Medical University Koshigaya Hospital

• Arai Takero

  Department of Anesthesiology, Dokkyo Medical University, Koshigaya Hospital

• Arai Takero

  Department Of Anesthesiology Dokkyo Medical University Koshigaya Hospital

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