Effects of a Sulfur-containing Compound in Green Sea Algae, Dimethylsulfoniopropionate, on the Outgrowth of Neurites from Pheochromocytoma Cells

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Effects of dimethylsulfoniopropionate (DMSP) at the concentrations of 10^<-6>, 10^<-5> and 10^<-4>M on the appearance of neurites from pheochromocytoma (PC-12) cells were examined on an RPMI 1640 medium containing 10% horse serum, 5% fetal bovine serum, penicillin and streptomycin in Petri dishes with and without the coats of collagen and poly-D-lysine, in which the nerve growth factor (NGF) was commonly excluded. The results indicated that the concentration of DMSP at 10^<-5>M and then at 10^<-6>M significantly accelerates the appearance of one and two neurites from the cells on the 2nd and 4th day in the dishes without polymer-coats, and noticeably elevates the number of neurite-bearing cells also in the collagen- and poly-D-lysine-coating dishes with increasing incubation time.
甲子園大学の論文
2007-03-31