Electroreduction of the Muscle Relaxant Drug Dantrolene Sodium at the Mercury Electrode and Its Determination in Bulk Form and Pharmaceutical Formulation

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概要

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• The electroreduction of the muscle relaxant drug dantrolene sodium at the mercury electrode has been studied in the Britton-Robinson universal buffer of pH 2.5-11.5 containing 20% (v/v) methanol by means of dc-polarography, cyclic voltammetry and controlled-potential coulometry. Its reduction took place via three irreversible cathodic steps in solutions of pH≤6, two steps in solutions of 6<pH<10 and a single step at pH values≥10 through the consumption of 10, 8 or 4 electrons, respectively. This behavior was attributed to the reduction of NO_2 group (1st and 2nd steps at pH≤6 or the single step at pH≥10) and the-CH=N-double bond (3rd step at pH<10). Two polarographic procedures (direct current and differential-pulse modes) and three adsorptive cathodic stripping voltammetric procedures (linear-sweep, differential-pulse and square-wave modes) were described and successfully applied for quantification of dantrolene sodium in its bulk form and in pharmaceutical formulation (Dantrolex tablets).

• 公益社団法人日本薬学会の論文
• 2007-10-01

著者

• Ghoneim Enass

  Chemistry Department Faculty Of Science Tanta University

関連論文

• Electroreduction of the Muscle Relaxant Drug Dantrolene Sodium at the Mercury Electrode and Its Determination in Bulk Form and Pharmaceutical Formulation

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