Selective Synthesis and Utility of One Tripyrrolic Compound and Its Intermediates

概要

論文の詳細を見る
Highly selective syntheses of tri (2, 4-dimethyl-3-carbethoxypyrrolyl)-methane 8 and its dipyrrolic intermediate 6 and pyrrolic one 1 are described based on the successful correction of the wrong process for 1 in literature. Tripyrrolic compounds have attracted much attention recently and been developed in diverse fields. 1 was the key intermediate for some tyrosine kinase inhibitors, including newly-launched Sutent^[○!R], and most recently we have found 6 was also synthetically useful in the synthesis of 11 that has been discovered as a novel histone deacetylases (HDAC) inhibitor with an IC_<50> value of about 1μM in our assessments and represents a promising lead for the development of more potent histone deacetylase inhibitors (HDACIs).
公益社団法人日本薬学会の論文
2007-10-01