Effects of Bradykinin on Aortic Endothelial Function in ApoE-Knockout Mice With Chronic Chlamydia Pneumoniae Infection

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概要

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• Background Impaired muscarinic receptor-mediated vasodilation is an important feature of early atherosclerosis. Earlier studies on apolipoprotein E-knockout mice (apoE-KO) mice suggested adverse effects of Chlamydia pneumoniae infection on the endothelial vasomotor responses of aortas to the muscarinic agonist methacholine. Using additional aorta samples the present study investigated the responses to bradykinin. Methods and Results ApoE-KO mice were repeatedly inoculated with either Chlamydia pneumoniae (C. pneumoniae) or saline. At 2, 6, and 10 weeks after the first inoculation, precontracted aorta rings from both groups were exposed to bradykinin in the absence and presence of L-NAME and diclofenac. In noninfected animals, the vasomotor responses to bradykinin were similar at all timepoints (p>0.5). Compared with noninfected animals, the responses in infected animals tended to increase through the study period (p<0.05 at 10 weeks). Although diclofenac and L-NAME had no effect in noninfected mice, they inhibited the responses to bradykinin in infected mice at 6 and, more markedly, 10 weeks (p<0.05 for both). Conclusion Bradykinin stimulation of aorta endothelium from C. pneumoniae-infected apoE-KO animals appears to activate compensatory kinin receptor-related mechanisms that could involve nitric oxide and vasore-laxing prostanoids. Although the precise molecular mechanisms require further investigation, one could speculate that strategies increasing bradykinin availability might reverse the arterial dysfunction during chronic infectious disease.

• 社団法人日本循環器学会の論文
• 2007-08-20

著者

• Liuba Petru

  Departments Of Pediatric Cardiology Lund University Hospital And University Of Lund

• Pesonen Erkki

  Departments Of Pediatric Cardiology Lund University Hospital And University Of Lund

• Karnani Paivi

  Department of Pharmacology and Toxicology, University of Helsinki

• Paakkari Ilari

  Department of Pharmacology and Toxicology, University of Helsinki

• Persson Kenneth

  Departments of Medical Microbiology, Lund University Hospital and University of Lund

• Forslid Anders

  Laboratory Animal Science, Lund University Hospital and University of Lund

• Paakkari Ilari

  Department Of Pharmacology And Toxicology University Of Helsinki

• Karnani Paivi

  Department Of Pharmacology And Toxicology University Of Helsinki

• Persson Kenneth

  Departments Of Medical Microbiology Lund University Hospital And University Of Lund

• Forslid Anders

  Laboratory Animal Science Lund University Hospital And University Of Lund

関連論文

• Effects of Bradykinin on Aortic Endothelial Function in ApoE-Knockout Mice With Chronic Chlamydia Pneumoniae Infection

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