PE-460 Oral Administration of Eicosapentaenoic Acid Reduces and Stabilizes Atherosclerotic Lesions through Lipid-Lowering-Independent Mechanism in ApoE-Deficient Mice(Infection/Inflammation/Immunity-2, The 71st Annual Scientific Meeting of the Japanese Ci
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概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2007-03-01
著者
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Sata Masataka
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Nagai Ryouzou
Department of Cardiovascular Medicine, The University of Tokyo
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Nagai Ryouzou
Department Of Cardiovascular Medicine Graduate School Medicine University Of Tokyo
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Nagai Ryozo
Department Of Cardiology University Of Tokyo
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Sata Masataka
Department Of Cardiology University Of Tokyo
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Sata Masataka
Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T
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Soma Masaaki
Mochida Pharmaceutical Co. Ltd.
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Matsumoto Miwa
Department Of Cardiology University Of Tokyo
関連論文
- Role of Adiponectin in Preventing Vascular Stenosis : The Missing Link of Adipo-Vascular Axis
- PE-566 Variations in the Origins of Mature Smooth Muscle Cells with SM1/2 Expression in Vascular Remodeling(Development and differentiation-3 (M) PE97,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
- OE-236 Genetic Deletion of Angiotensin-converting Enzyme 2 Exacerbates Neointimal Hyperplasia after Wire-mediated Endovascular Injury with Regional Severe Inflammation(OE40,Atherosclerosis, Basic 2 (IHD),Oral Presentation (English),The 73rd Annual Scienti
- OJ-230 Recruitment of Bone-Marrow-Derived Stem Cells after Coronary Stent Implantation and Its Clinical Significance(Restenosis, basic/clinical-2 (IHD) OJ39,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- Hematopoietic stem cells differentiate into vascular progenitor cells that contribute to atherosclerosis
- 4 Bone marrow-derived cells contribute to vascular wall inflammation without differentiating into smooth muscle cells(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Angiotensin II, but Not Catecholamines, Stimulates Transformation of Bone Marrow Cells to Cardiomyocytes
- OE-292 Function and Role of Voltage-gated Sodium Channel (NaV1.7) Expressed in Aortic Smooth Muscle Cells(Vascular smooth muscle (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-335 Effect of Peak and Endurance Exercises on the Number of Circulating Endothelial Progenitor Cells (EPCs)(Exercise test/Cardiac rehabilitation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Stromal Cell-Derived Factor-1α Gene Transfer Induces Therapeutic Angiogenesis by Recruiting Endothelial Progenitor Cells via the VEGF/eNOS Pathway
- Load dependence of calcium transient of a single cardiac myocyte revealed by a novel force-calcium measurement system
- PJ-687 Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital(PJ115,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-579 Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan(PJ097,Cardiovascular Pharmacology (Clinical) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PJ-391 Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(PJ066,ACS/AMI (Basic) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PE-553 Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System(PE093,Echo/Doppler (Others) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- PE-494 Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd A
- PE-381 Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation : Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent(PE064,Coronary Revascularization, PCI (DES) 6 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the
- PE-347 Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy : the Utility of Cardiac Magnetic Resonance(PE058,Cardiomyopathy/Hypertrophy (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The
- PE-342 Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy(PE058,Cardiomyopathy/Hypertrophy (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meet
- PE-110 Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments(PE019,Echo/Doppler (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- DPJ-022 Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- DPE-042 Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension(DPE07,Hypertension, Clinical (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-001 Long-Term Local Inflammatory Response after Coronary Artery Stenting : BMS vs. SES vs. PES(OJ01,Coronary Revascularization, PCI (DES) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-366 Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency(OE62,Peripheral Circulation/Vascular Disease (Therapy) (H),Oral Presentation (English),The 73rd Annual Sc
- OE-213 Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia(OE36,Atherosclerosis (Clinical/Treatment) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting
- OE-179 Effect of Ghrelin on Autonomic Activity in Healthy Volunteers(OE31,Cardiovascular Pharmacology (Basic) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-094 Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats without affecting Infarction Volume(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation So
- PJ-654 Post-ischemic Administration of Fluvastatin Improves Cognitive Dysfunction in the Chronic Stage of Cerebral Infarction in Rat Model(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meet
- Candesartan Ameliorates Cardiac Dysfunction Observed in Angiotensin-Converting Enzyme 2-Deficient Mice
- 5 Vascular Injury-induced Upregulation of Epac1 Counteracts PKA, Promoting Smooth Muscle Cell Migration and Neointimal Thickening(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Endothelial Responses of the Aorta from Adrenomedullin Transgenic Mice and Knockout Mice
- OE-321 Accumulation of primitive cells in intracoronary thrombi : Temporal analysis of cellular-constituents of the thrombotic materials in patients with myocardial infarction(Acute myocardial infarction, clinical(pathophysiology)(01)(IHD),Oral Presentati
- PJ-427 Early Accumulation of Primitive Cells into Intracoronary Thrombi in Patients with Acute Coronary Syndrome(Thromboembolism/Antithrombotic therapy/Thrombolysis-4 (H) PJ72,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- OE-301 "Black-hole phenomenon" may contribute to positive vascular remodeling with stent malapposition after implantation of sirolimus-eluting stents in swine coronary arteries(Intravascular endoscopy/Intravascular ultrasound(01)(I),Oral Presentation(Engl
- FRS-098 TNF-α Is Involved in Neointimal Formation after Vascular Injury Through Its Inflammatory Effects to Induce Bone Marrow Cells(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
- PE-209 Pitavastatin Excretes eNOS-independent Protective Action against Angiotensin II-induced Atrial Remodeling through Attenuating Rac1-madiated Oxidative Stress(PE035,Cardiovascular Pharmacology (Basic) (H),Poster Session (English),The 73rd Annual Scie
- PE-427 Blockade of Angiotensin II Type 1 Receptor Attenuates the Post-Infarcted Cardiac Dysfunction in Angiotensin-converting Enzyme 2 Deficient Mice(Heart failure, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-127 Local Delivery of Slow-releasing Synthetic Prostaglandin 12 Agonist Augments Collateral Growth in Swine Chronic Cardiac Ischemia Model(Myocardial ischemia/reperfusion, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation
- OE-104 A Synthetic Prostaglandin I2 Agonist Up-regulates Endogenous Growth Factors Via c-AMP Mediated Pathway and Promotes Therapeutic Angiogenesis(Growth factor/Cytokine-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Diverse Contribution of Bone Marrow-derived Cells to Vascular Remodeling Assoclated with Pulmonary Arterial Hypertension and Arterial Neointimal Formation(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-129 Targeted Disruption of Angiotensin-converting Enzyme 2 Deteriorates Cardiac Performance(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-008 Local Delivery of Slow-releasing Synthetic Prostaglandin 12 Agonist Augments Collateral Growth in Swine Chronic Cardiac Ischemia Model(Chronic coronary heart disease/Remodeling-1 (IHD) OE2,Oral Presentation (English),The 70th Anniversary Annual Sci
- Adipose Tissues Contain Side Population (SP) Cells(Apoptosis/Necrosis/Regeneration 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Local Delivery of Slow-releasing Synthetic Prostaglandin I_2 Agonist Augments Collateral Growth in Swine Chronic Cardiac Ischemia Model
- Direct Injection of Synthetic Prostaglandin 12 Agonist Stimulates Expression of Endogenous Growth Factors and Inhibits Cardiac Remodeling after Myocardial Infarction(Acute Myocardial Infarction, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Jap
- Targeted Disruption of Angiotensin-converting Enzyme 2 Results in Spontaneous Heart Failure(Heart Failure, Basic 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-562 Reconstituted High-Density Lipoprotein Promotes Differentiation of Endothelial Progenitor Cells and Augments Ischemia-induced Angiogenesis(Regeneration (angiogenesis/myocardial regeneration)-3, The 71st Annual Scientific Meeting of the Japanese Cir
- PE-564 Dehydroepiandrosterone Sulfate is an Antivascular Remodeling Factor(PE095,Atherosclerosis (Clinical/Pathophysiology) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-065 A Combination of Erythropoietin Administration with Autologous Blood Donation for Therapeutic Angiogenesis(DPE11,Kidney/Renal Circulation/CKD (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- FRS-018 Fibroin, a Silk-based Biodegradable Protein, is a Promising Material to Engineer Small-diameter Vascular Graft(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-573 Phosphodiesterase-5 Inhibition and cGMP Promote Ischemia-induced Angiogenesis through Inducing Vascular Endothelial Growth Factor Production via the Hypoxia Inducible Factor-1 Pathway(Regeneration(angiogenesis/myocardial regeneration)(03)(M),Poster
- PE-153 Acceleration of Hyperlipidemia-induced Atherosclerosis in Angiotensin-converting Enzyme 2 and Apolipoprotein E Double-mutant Mice(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
- FRS-040 One-year Patency of a Small-diameter Vascular Graft Made of Fibroin, a Silk-based Biodegradable Material(Peripheral Vascular Disease(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Genetic Deletion of Angiotensin-converting Enzyme 2 Accelerates Hyperlipidemia-induced Atherosclerosis in Apolipoprotein E-deficient Mice(Plenary Session 3 (PL-3) (IHD) Roles of Inflammation and Immunity in Atherosclerosis,Special Program,The 72nd Annua
- OE-322 A Combination of a Cyclic GMP-specific Phosphodiesterase-5 Inhibitor, Vardenafil, and Nicorandil Ameliorates Synergistically Monocrotaline-induced Pulmonary Arterial Hypertension in Rats(Pulmonary circulation-1, The 71st Annual Scientific Meeting o
- FRS-059 cGMP-specific Phosphodiesterase-5 Inhibition Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and the Recruitment of Endothelial Progenitor Cells(Regeneration, The 71st Annual Scientific Meeting of the Japanese Circula
- 3 Nicorandil Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats : The Promising Therapeutic Potential of a Novel Combination Therapy(Diagnosis and Treatment of Pulmonary Hypertension, The 71st Annual Scientific Meeting of the Japanes
- 2 Long-term Patency of a Small Diameter Vascular Prosthesis Made of Fibroin, a Silk-based Biodegradable Material(Regeneration Therapy Using Tissue Engineering, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-620 Diverse Contribution of Bone Marrow-derived Cells to Vascular Remodeling between Carotid Arteries Injured Mechanically and Pulmonary Vasculature Injured by Monocrotaline(Regeneration (angionenesis/myocardial regeneration)-6 (M) PE110,Poster Session
- PE-277 The Potential Therapeutic Efficacy of Cyclic GMP-specific Phosphodiesterase-5 Inhibition for Angiogenesis in a Mouse Hindlimb Ischemia Model(Peripheral circulation-5 (H) PE47,Poster Session (English),The 70th Anniversary Annual Scientific Meeting o
- OJ-191 A Silk-based Biodegradable Artificial Blood Vessel for Small Artery(Cardiovascular surgery/CABG-1 (IHD) OJ32,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- A Highly Purified Hematopoietic Stem Cell Does Not Substantially Contribute to Vascular Remodeling after Mechanical Injury(Development and Differentiation 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Bone Marrow-derived Cells Do Not Contribute Appreciably to the Pulmonary Arterial Remodeling in Rats with Monocrotaline-induced Pulmonary Hypertension(Pulmonary Circulation 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Heparin Cofactor II as a Novel Vascular Protective Factor Against Atherosclerosis
- FRS-014 Adremedullin augments collateral development and mobilization of endothelial progenitor cells (EPCs) in response to acute ischemia(Angiogenesis and Regeneration Medicine in Cardiovascular Medicine (M) : FRS3)(Featured Research Session (English))
- OJ-056 Augmented Angiogenesis in Adventitia Promotes Plaque Progression in Apolipoprotein E-deficient Mice(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Primitive Stem Cell and Its Pathogenesis of Intracoronary Thrombi in ACS Patients(Thrombosis/Thrombolysis 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Temporal Analysis of Cellular Constituents of Intracoronary Thrombi in ACS Patients Aspirated Through Thrombectomy(Acute Coronary Syndrome, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-119 Adipocytokine Profile of the Periadventitial Adipose Tissue after Endovascular Injury(Infection/Inflammation/Immunity(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-059 Atheroprotective Effect of Perivascular Adipose Tissue in Neointimal Formation after Angioplasty(New Insights into Metabolic Syndrome(02)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Bone Marrow-derived SM1-positive Smooth Muscle Cells Contribute to Physiological Neovascularization, but Not to Neointimal Formation(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Molecular physiology, a novel approach to cardiac fucntion
- OE-025 Obesity Augments Neointimal Hyperplasia after Angioplasty(OE05,Obesity/SAS (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell
- Flow-Mediated Vasodilation as a Diagnostic Modality for Vascular Failure
- Novel Angiogenic Effects of a New HMG-CoA Reductase Inhibitor, Pitavastatin
- Critical roles of IKLF/BTEB2 in vascular remodeling proved by gene targeting
- PE-035 Perivascular Adipose Tissues Anatomically Communicate with Atherosclerotic Lesions via Vasa Vasorum : Possible Link of Adipovascular Axis(Atherosclerosis, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Bone Marrow-Derived Cells Play a Critical Role in Progression and Destabilization of Atherosclerotic Plaques(A New Era in Atherosclerosis Research, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-629 Perivascular Fats Anatomically Communicate with Atherosclerotic Lesions via Vasa Vasorum; Possible Link of Adipo-vascular Axis(Atherosclerosis, basic-6 (H) PJ106,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- PE-158 Circulating Progenitors Contribute to Neointimal Formation in Non-irradiated Bone Marrow Chimeric Mice(Atherosclerosis, basic-4 (H) PE27,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Sirolimus Inhibits Differentiation of Circulating Vascular Progenitor Cells and Prevents Neointimal Hyperplasia(Restenosis after Angioplasty, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Statins Inhibit Differentiation of Smooth Muscle Progenitor Cells(Lipid Disorders 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Circulating Progenitors Contribute to Neointimal Formation in Non-irradiated Bone Marrow Chimeric Mice(Atherosclerosis, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Microbubble-induced increase in ablation of liver tumors by high-intensity focused ultrasound
- Gene Transfer of Adrenomedullin Augments Collateral Development in Response to Acute Ischemia
- PE-126 The Additional Effects of Rosuvastatin on Atherosclerosis Independent of Cholesterol-lowering Actions(Atherosclerosis, basic-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 3 An Important role for renin angiotensin system in vulnerable plaque formation(AHA-JCS Joint Symposium (AHA-JCS Joint Symposium) (IHD) Vulnerable Plaques : Pathogenesis and Noninvasive Approaches to Detection,Special Program,The 72nd Annual Scientific Me
- PE-032 Deletion of Angiotensin II Type I Receptor in Bone Marrow Reduced Atherosclerotic Lesion Formation in ApoE Deficient Mice(Atherosclerosis, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-359 Fluvastatin Accelerates Re-endothelialization Impaired by Local Sirolimus Treatment(Endothelium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Angiotensin II Type 1 Receptor in Bone Marrow Plays a Crucial Role in Plaque Progression and Destabilization(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-633 Blockade of Angiotensin II Type1 Receptor Inhibits Atherosclerotic Lesion Formation and Stabilizes Plaque Contents(Atherosclerosis, basic-6 (H) PJ106,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- Contribution of Bone Marrow Derived Smooth Muscle Progenitor Cells in the Pathogenesis of Aortic Aneurysm Formation Induced by Angiotensin II(The Frontier of Atherosclerosis Research (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
- OJ-299 Potent Inhibitory Effects of Sirolimus on Circulating Smooth Muscle Progenitor Cells(Restenosis after Angioplasty, Basic/Clinical 2 (IHD) : OJ36)(Oral Presentation (Japanese))
- OJ-065 Statins Inhibit Differentiation of Smooth Muscle Progenitor Cells(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))
- OE-163 Genetic visualization of differentiation in living cells : Potential applications of a transgenic mouse that expresses EGFP in smooth muscle(Restenosis after Angioplasty, Basic/Clinical 1 (IHD) : OE20)(Oral Presentation (English))
- FRS-124 Hyperlipidemia Increases the Number of Circulating Smooth Muscle Progenitor Cells(Metabolic Syndrome (H) : FRS15)(Featured Research Session (English))
- 7 Potent Inhibitory Effects of Sirolimus on Circulating Smooth Muscle Progenitor Cells(Plenary Session 4 (PL4) (IHD) : Restenosis after PCI 2003 : New Therapies for the Next Generation)(Special Program)
- The Renin-Angiotensin System : A Potential Modulator of Endothelial Progenitor Cells
- Role of Aberrant Iron Homeostasis in the Upregulation of Transforming Growth Factor-β1 in the Kidney of Angiotensin II-Induced Hypertensive Rats