Comparison of Newly Developed Inhalation Anesthesia System and Intraperitoneal Anesthesia on the Hemodynamic State in Mice(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• KNI-472 is the first anesthetic system for mice and rats to incorporate a ventilator. It consists of a newly developed syringe pump-type vaporizer and gas monitor that can deliver accurate concentrations of anesthetic gas at an extremely low airflow. In this study, we compared the hemodynamic effects of isoflurane anesthesia using KNI-472 and intraperitoneal pentobarbital anesthesia. In the isoflurane anesthetic group, Institute of Cancer Research (ICR) mice were anesthetized with 5% isoflurane, followed by endotracheal intubation. Subsequently, they were ventilated mechanically, and anesthesia was maintained with 2% isoflurane for a 60-min period using KNI-472. In the pentobarbital anesthetic group, the ICR mice were anesthetized by an intraperitoneal injection of sodium pentobarbital (70mg/kg). In isoflurane anesthesia, the heart rate (HR) and mean blood pressure (MBP) were stable. In contrast, in pentobarbital anesthesia, MBP decreased in the first stage after the initiation of anesthesia, after which it gradually increased. The intra-group variability in the estimated skin blood flow (SBF) was higher in the pentobarbital anesthesia than that in the isoflurane anesthesia. The PaO_2 and PaCO_2 values at 15min after the initiation of pentobarbital anesthesia revealed hypoxia and hypercapnia compared with isoflurane anesthesia. In this study, isoflurane anesthesia using KNI-472, unlike pentobarbital anesthesia, did not induce changes in MBP, SBF, or blood gases. The changes induced by pentobarbital anesthesia were attributed to a change in the depth of anesthesia with time. These results indicate that inhalation anesthesia using KNI-472 is suitable in research on the hemodynamic state in mice.

• 公益社団法人日本薬学会の論文
• 2007-09-01

著者

• Inoue Masaaki

  S.k.i. Net. Inc.

• Inoue Masaaki

  S.k.i. Net Inc.

• MATSUDA Yoshikazu

  Department of Integrative Physiology & Bio-System Control, Shinshu University School of Medicine

• OHSAKA Kazumasa

  Department of Integrative Physiology & Bio-System Control, Shinshu University School of Medicine

• YAMAMOTO Hidekazu

  Natsume Seisakusho Co., Ltd.

• NATSUME Katsuhiko

  Natsume Seisakusho Co., Ltd.

• HIRABAYASHI Shirokazu

  Leaf International Inc.

• KOUNOIKE Masayoshi

  Senko Medical Instrument Inc.

• Matsuda Yoshikazu

  Department Of Integrative Physiology & Bio-system Control Shinshu University School Of Medicine

• Yamamoto Hidekazu

  Natsume Seisakusho Co. Ltd.

• Ohsaka Kazumasa

  Department Of Integrative Physiology & Bio-system Control Shinshu University School Of Medicine

• Natsume Katsuhiko

  Natsume Seisakusho Co. Ltd.

関連論文

• Comparison of Newly Developed Inhalation Anesthesia System and Intraperitoneal Anesthesia on the Hemodynamic State in Mice(Pharmacology)
• Successful Becanalization by In-Stent Percutaneous Transluminal Angioplasty With Distal Protection for Acute Carotid Stent Thrombosis : Case Report
• Pilot Study of a Dissection Table for Gross Anatomy Laboratory Equipped with a Photocatalytic Device that Decomposes Formaldehyde
• Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
• NARCOBIT-A Newly Developed Inhalational Anesthesia System for Mice
• Development of inhalation anesthetic apparatus for small laboratory animals
• 88 Actual situation of the insulin therapy for pre-school age type l diabetes patients in Japan

スポンサーリンク