PTEN : Its Deregulation and Tumorigenesis(Metabolism and Functions of Phosphoinositides)

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概要

• 論文の詳細を見る

• The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of upstream regulatory factors for PTEN and unveiled that the impairment in the PTEN regulatory system potentially becomes a causal factor for oncogenic transformation of cells. This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators.

• 公益社団法人日本薬学会の論文
• 2007-09-01

著者

• MAEHAMA Tomohiko

  Department of Physiological Chemistry, Faculty of Phamaceutical Science, The University of Tokyo

• Maehama Tomohiko

  Department Of Biochemistry And Cell Biology National Institute Of Infectious Diseases

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• Activation of c-Jun N-Terminal Kinase (JNK) by Lysophosphatidic Acid in Swiss 3T3 Fibroblasts
• PTEN : Its Deregulation and Tumorigenesis(Metabolism and Functions of Phosphoinositides)

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