The Phosphoinositide Kinase PIP5K That Produces the Versatile Signaling Phospholipid PI4,5P_2(Metabolism and Functions of Phosphoinositides)
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概要
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The phosphoinositide kinase, phosphatidylinositol 4-phosphate 5-kinase (PIP5K), produces the versatile phospholipid phosphatidylinositol 4,5-bisphosphate (PI4,5P_2), through which PIP5K plays crucial roles in a wide variety of cell functions. So far, three PIP5K isozymes and splicing variants have been identified. We speculate that each PIP5K isozyme or splicing variant is activated in a tempo-spatially different manner, due to the existence of activators or recruiters specific to each isozyme: this tempo-spatially different activation of PIP5K produces PI4,5P_2 at different compartments of the cell at different times, which phenomenon may be responsible for the apparent multifunction of PI4,5P_2/PIP5K. Accumulating evidence supports this notion that each PIP5K isozyme is activated by its specific activator and plays a crucial role in a unique cell function. In this article, we describe recent advances regarding the PIP5K isozyme-specific activation mechanisms and physiological functions.
- 2007-09-01
著者
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Kobayashi-nakano Akiko
Department Of Physiological Chemistry Graduate School Of Comprehensive Human Sciences Institute Of B
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KANAHO Yasunori
Department of Life Science, Tokyo Institute of Technology
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YOKOZEKI Takeaki
Department of Physiological Chemistry, Graduate School of Comprehensive Human Sciences, Institute of
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Kanaho Yasunori
Department Of Physiological Chemistry Graduate School Of Comprehensive Human Sciences Institute Of B
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Yokozeki Takeaki
Department Of Physiological Chemistry Graduate School Of Comprehensive Human Sciences Institute Of B
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KANAHO Yasunori
Department of Life Science, Tokyo Institute of Technolgoy
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