Inhibitory Effect of Succinic Acid on Epithelial Cell Proliferation of Colonic Mucosa in Rats

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概要

• 論文の詳細を見る

• Microbial breakdown of carbohydrates in the large intestine mainly produces short-chain fatty acids (SCFA). SCFA stimulate epithelial cell proliferation of the digestive tract in vivo. Succinic acid sometimes accumulates in the colonic lumen. However, the effect of succinic acid on colonic epithelial cell proliferation is unknown. Thus, we planned to clarify the influence of succinic acid on colonic epithelial cell proliferation in vivo. We continuously administered infusate with or without succinic acid (100 mM) into the distal colon of rats for 6 d and measured accumulated mitosis per crypt of distal colon of these rats. Succinic acid infused into rat colons significantly inhibited colonic cell proliferation and reduced crypt size. These results clearly indicated the inhibitory effects of succinic acid on colonic epithelial cell proliferation in vivo.

• 日本ビタミン学会の論文

著者

• Inagaki Akiko

  School Of Science And Engineering Ishinomaki Senshu University

• Sakata Takashi

  School Of Science And Engineering Ishinomaki Senshu University

• ICHIKAWA Hirofumi

  The Second Department of Surgery, Tohoku University School of Medicine

• Ichikawa Hirofumi

  The Second Department Of Surgery Tohoku University School Of Medicine

関連論文

• Insoluble Dietary Fiber of Wheat Bran Increased Viscosity of Pig Whole Cecal Contents in Vitro
• Inhibitory Effect of Succinic Acid on Epithelial Cell Proliferation of Colonic Mucosa in Rats
• Dose-Dependent Stimulatory and Inhibitory Effects of Luminal and Serosal n-Butyric Acid on Epithelial Cell Proliferation of Pig Distal Colonic Mucosa

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