Frequent Premature Ventricular Contractions Induced by Itraconazole
スポンサーリンク
概要
- 論文の詳細を見る
Itraconazole is widely used to treat onychomycosis because of its significant therapeutic effects. An otherwise healthy 30-year-old man treated with itraconazole developed frequent premature ventricular contractions (PVC). He presented with a dry cough and palpitation. The results of 12-lead electrocardiography (ECG) were essentially normal, but Holter ECG revealed 17,484 (18%) uniform PVC, including 4 short runs among 96,930beats/day. Another Holter ECG after withdrawing itraconazole revealed 1,032 premature atrial contractions but no PVC. The corrected QT interval was 0.39s without itraconazole, 0.41s with itraconazole, and 0.43s when multiple PVC were documented. Itraconazole inhibits the fungal cytochrome P450 that is involved in fungal cell membrane formation, interrupts human cytochrome P450A4 in the liver and causes adverse interactions with various drugs such as antiarrythmics, but its cardiac side-effects are obscure. Both patients and physicians should be aware that itraconazole can cause PVC as a side-effect.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
-
Fukunami Masatake
Department of Statistics and Information Science, Toyama Medical Pharmaceutical University
-
Fukunami Masatake
Department Of Cardiology Osaka General Medical Center
-
Okamoto Junko
Department of Cardiovascular Surgery, Kinki University School of Medicine
-
Kioka Hidetaka
Department of Cardiology, Osaka General Medical Center
-
Okamoto Junko
Department Of Cardiovascular Surgery Kinki University School Of Medicine
-
Kioka Hidetaka
Department Of Cardiology Osaka General Medical Center
関連論文
- Double-Blind Placebo-Controlled Trial of Aprindine and Digoxin for the Prevention of Symptomatic Atrial Fibrillation
- PJ-648 The Depression Rate of Renal Function is Associated with Cardiovascular Death in Patients with Chronic Heart Failure and Renal Failure(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-633 Usefulness of Cardiac I-123 Metaiodobenzylguanidine Imaging for Predictor of Sudden Cardiac Death in Patients with Mild to Moderate Systolic Dysfunction(PJ106,Nuclear Cardiology (Others) (I),Poster Session (Japanese),The 73rd Annual Scientific Meet
- PJ-159 Successful Automatic Detection of Atrial Fibrillation Episodes by Pulse Oximetry(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-818 Prevention of Contrast-Induced Nephropathy with Sodium Bicarbonate in Patients Undergoing an Emergent Cardiac Catheterization : A Prospective Randomized Controlled Trial(Kidney/Renal circulation-6, The 71st Annual Scientific Meeting of the Japanese
- PJ-605 A Novel Method for Detecting Even Asymptomatic Atrial Fibrillation Episode with Pulse Oximetry(Arrhythmia, diagnosis/pathophysiology/EPS-13 (A) PJ102,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- Frequent Premature Ventricular Contractions Induced by Itraconazole
- PJ-311 The Effect of Carvedilol and Amlodipine on LV Diastolic Function in Patients with Congestive Heart Failure(Heart Failure, Clinical 6 (M) : PJ52)(Poster Session (Japanese))
- PJ-054 Prediction of Transition to Chronic Atrial Fibrillation by Time Course of P Wave Duration Dispersion After Conversion of Atrial Fibrillation(ECG/Body Surface Potential Mapping/Holler 1 (A) : PJ10)(Poster Session (Japanese))
- OJ-319 Prediction of Sudden Death in Chronic Heart Failure : A Prospective Comparative Study of Cardiac MIBG Imaging and Heart Rate Variability(Nuclear Cardiology 7 (I) : OJ38)(Oral Presentation (Japanese))
- OJ-306 Long-Term Effect of Statin on Exercise Tolerance, Cardiac Function and Clinical Outcome in Patients With Ischemic Chronic Heart Failure(Heart Failure, Clinical 9 (M) : OJ37)(Oral Presentation (Japanese))
- Carvedilol Reduces the Spatial Dispersion of Filtered QRS Duration in Patients with Chronic Heart Failure
- PJ-203 A Novel Method to Detect Even Asymptomatic Atrial Fibrillation Episode with Pulse Oximetry(Arrhythmia, diagnosis/pathophysiology/EPS-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-787 Serial Cardiac MIBG Imagings Improve the Prediction of Cardiac Death in Patients With Chronic Heart Failure after Carvedilol Therapy(Nuclear cardiology-9 (H) PJ138,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
- PJ-768 What is the Determinant Factor of Exercise Capacity in Patients With Chronic Heart Failure?(Heart failure, clinical-20 (M) PJ133,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-407 Decreased Renal Function as a Predictor of Sudden Death in Patients Admitted for Decompensated Heart Failure-a Prospective Study(Heart failure, clinical-12 (M) PJ69,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Jap
- PJ-252 Prediction of Sudden Death with Chronic Heart Failure : A Prospective Comparative Study of Cardiac I-123 Metaiodovenzylguanidine Imaging and QT Dispersion(Nuclear cardiology-4 (I) PJ43,Poster Session (Japanese),The 70th Anniversary Annual Scientifi
- PJ-235 Long Term Clinical Outcome of Contrast Induced Nephropathy after Urgent Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients(Kidney/Renal circulation-5 (H) PJ40,Poster Session (Japanese),The 70th Anniversary Annual Scientific
- PE-470 Metabolic Syndrome Influences the Effect of ACE Inhibitors on Morbidity and Mortality in Patients with Chronic Heart Failure(Heart failure, clinical-7 (M) PE79,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- OJ-075 Long-Term Effect of Atorvastatin on Neurohumoral Activation and Cardiac Function in Chronic Heart Failure-a Prospective Randomized Placebo-Controlled Study(Heart failure, clinical-3 (M) OJ13,Oral Presentation (Japanese),The 70th Anniversary Annual
- OE-090 Usefulness of P-wave Signal-Averaged ECG for Evaluating Asymptomatic Atrial Fibrillation Episode Level Irrespectively of Drug Therapies(ECG/Body surface potential mapping/Holter-1 (A) OE15,Oral Presentation (English),The 70th Anniversary Annual Sci
- Decreased Renal Function as a Predictor of Sudden Death in Patients Admitted for Decompensated Heart Failure (Heart Failure, Clinical 12 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Reverse Left Ventricular Remodeling by Carvedilol Reduces the Spatial Dispersion of QRS Duration in Patients With Chronic Heart Failure (Heart Failure, Clinical 10 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Spironolactone on the Spatial Dispersion of Filtered QRS Duration in Patients With Mild to Moderate Chronic Heart Failure (Heart Failure, Clinical 10 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Effect of ACE Inhibitors on Atrial Electrical Remodeling in Patients With Congestive Heart Failure(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of Effects of Xanthine Oxidase Inhibitor and Uricosuric Agent on Clinical Outcome in Patients with Heart Failure and Hyperuricemia(Heart Failure, Clinical 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Atorvastatin Improves Cardiac Function in Patients With Chronic Heart Failure : A Prospective Randomized Placebo-Controlled Study(Heart Failure, Clinical 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)