Interleukin-10 Associates With Adiponectin Predominantly in Subjects With Metabolic Syndrome
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概要
- 論文の詳細を見る
Background Inflammation and the metabolic syndrome (MetS) are important risk factors in cardiovascular disease. There is accumulating evidence that decreased adiponectin levels are associated with MetS. Recently, it was shown that adiponectin induces the expression of a potent anti-inflammatory cytokine, interleukin (IL)-10, in vitro. The aim of this study is to investigate the association of IL-10 levels with other pro-inflammatory and anti-inflammatory factors including adiponectin levels in vivo. Methods and Results MetS components were assessed in 117 drug-naive middle-aged men. Serum levels of high-sensitive C-reactive protein (hs-CRP), IL-6, adiponectin, IL-10 and tumor necrosis factor-α (TNF-α) were measured in these subjects. A significant decrease in adiponectin (5.15±1.79μg/ml vs 6.87±3.55μg/ml, p<0.02) and an increase in IL-6 (1.50±1.50pg/ml vs 1.06±0.78pg/ml, p<0.05) levels were associated with MetS. The serum IL-10 level exhibited a significant positive correlation with IL-6, hs-CRP, and TNF-α levels, but not with adiponectin in healthy individuals. However, IL-10 exhibited a significant correlation with adiponectin, especially in the subjects with MetS. Conclusions Serum IL-10 levels correlated with inflammatory proteins, but not with adiponectin. However, IL-10 positively associated with adiponectin especially in the subjects with MetS. IL-10 might be involved in the inflammatory network of MetS in relation to adiponectin.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
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Nishida Makoto
Health Care Center, Osaka University
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Nishida Makoto
Health Care Center Osaka University
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MORIYAMA Toshiki
Health Care Center, Osaka University
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Moriyama Toshiki
Health Care Center Osaka University
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Sugita Yoshiro
Health Care Center, Osaka University
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Sugita Yoshiro
Health Care Center Osaka University
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Yamauchi-takihara Keiko
Health Care Center Osaka University
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