Effect of Chronic Treatment with Clomipramine on Food Intake, Macronutrient Selection and Body Weight Gain in Rats(Miscellaneous)

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概要

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• Long-term treatment with clomipramine (CMI), a tricyclic antidepressant, induces food craving and body weight gain in patients. The present study investigated the effects of chronic treatment with CMI on total food intake, macronutrient selection, and body weight gain in rats. Male Wistar rats were maintained on a dietary selfselection regime with separate sources of protein, fat and carbohydrate. Animals received i.p. injections of CMI (0, 3, 10, 30 mg/kg) during 27 consecutive days. Food consumption and body weight were recorded daily and results were calculated as average of three consecutive days, namely during pre-treatment (3 d before pharmacological treatment), treatment (7th-9th; 16th-18th and 25th-27th days), and post-treatment (28th-33rd days). Results showed that CMI (30 mg/kg) significantly decreased energy intake during all treatment period, an effect that was related to a decrease in both carbohydrate-rich diet intake and body weight gain. At dose of 3 mg/kg CMI increased the total energy intake in the 16th-18th days, suggesting an apparent biphasic effect of chronic treatment with CMI on caloric intake. Chronic administration with CMI (27 d) did not alter protein-rich or fatrich diet consumption. The main result of this study indicated that chronic treatment with CMI decreases rather than increase food consumption and body weight gain in rats exposed to a macronutrient self-selection procedure.

• 公益社団法人日本薬学会の論文
• 2007-08-01

著者

• Nunes-de-souza Ricardo

  Laboratory Of Pharmacology School Of Pharmaceutical Sciences Sao Paulo State University

• Nunes-de-souza Ricardo

  Laboratory Of Pharmacolgy Sao Paulo State University

• CALEGARI Leonardo

  Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University

• GORENSTEIN Clarice

  Laboratory of Neuropsychopharmacology, Institute of Biomedical Sciences, University of Sao Paulo

• GENTIL Valentim

  Department and Institute of Psychiatry, University of Sao Paulo Medical Center

• PLANETA Cleopatra

  Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University

• Calegari Leonardo

  Laboratory Of Pharmacology School Of Pharmaceutical Sciences Sao Paulo State University:programa De

• Planeta Cleopatra

  Laboratory Of Pharmacology School Of Pharmaceutical Sciences Sao Paulo State University

• Gorenstein Clarice

  Laboratory Of Neuropsychopharmacology Institute Of Biomedical Sciences University Of Sao Paulo

• Gentil Valentim

  Department And Institute Of Psychiatry University Of Sao Paulo Medical Center

関連論文

• Effects of Erythrinian Alkaloids Isolated from Erythrina mulungu (Papilionaceae) in Mice Submitted to Animal Models of Anxiety(Pharmacology)
• Effect of Chronic Treatment with Clomipramine on Food Intake, Macronutrient Selection and Body Weight Gain in Rats(Miscellaneous)

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