Development of Environmentally Benign Organometallic Catalysis for Drug Discovery and Its Application
スポンサーリンク
概要
- 論文の詳細を見る
We have developed a novel organometallic catalysis and applied it to drug discovery. Two new catalysts were found, ruthenium hydride with a nitrogen-containing heterocyclic carbene (A) and an organopalladium catalyst supported on a sulfur-terminated semiconductor, gallium arsenide (001) (B). Both catalysts are environmentally benign, because A can yield indole derivatives with good atom economy, and B can catalyze the Mizoroki-Heck reaction more than 10 times with only trace amounts of leached palladium (ppb level). We also describe our synthetic study of nitrogen-containing heterocycles using ring-closing metathesis (RCM), such as chiral bicyclic lactams, azacycloundecenes, axially chiral macrolactams, 1,2-dihydroquinolines and indoles, including the development of silyl-enol ether ene metathesis, selective isomerization of terminal olefin, enamide metathesis and cycloisomerization and its application to the syntheis of 4 natural products, (-)-coniceine, (S)-pyrrolam A, angustureine, and fistulosin.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
関連論文
- Preparation of Tethered Palladium Catalysis Supported on Gold(111) and Its Surface Characterization by X-ray Photoelectron Spectroscopy (XPS)
- Highly Reactive Organopalladium Catalyst Formed on Sulfur-Terminated GaAs(001)-(2 × 6) Surface
- Novel Palladium Catalyst Supported on GaAs(001) Passivated by Ammonium Sulfide
- Novel Organopalladium Material Formed on a Sulfur-Terminated GaAs(001) Surface
- Total Synthesis and the Three-Dimensional Structure-Activity Relationship Study of Tripeptide Antibiotic Belactosin A, a Potent Proteasome Inhibitor
- Development of Environmentally Benign Organometallic Catalysis for Drug Discovery and Its Application
- Highly Reactive Organopalladium Catalyst Formed on Sulfur-Terminated GaAs(001)-($2 \times 6$) Surface