Curcumin Affects Development of Zebrafish Embryo(Pharmacognosy)

概要

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Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investigated in this study. The LD_<50> values of curcumin (24-h incubation) were estimated at 7.5μM and 5μM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
公益社団法人日本薬学会の論文
2007-07-01