Mechanical activity of frog esophagus muscle in response to electrical stimulation of intramural nerves

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概要

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• Microscopic observation of intramural nerves in the frog esophagus, fixed and stained with OsO_4 and ZnI_2, revealed that nerve cell bodies and bundles connecting the nerve cell bodies formed loose and irregular networks. The nerve cell bodies were mostly lying singly in the nerve bundles, with occasional observations of two closely linked nerve cell bodies. Isolated circular and longitudinal segments of esophageal muscle were spontaneously rhythmically contractile, with a frequency of 2.2-3.0 per min. This was not altered by tetrodotoxin (TTX). In longitudinal muscle segments, transmurally applied electrical stimulation produced contractile responses which were not inhibited by atropine or guanethidine, but were reduced in amplitude by TTX, suggesting a nonadrenergic-noncholinergic (NANC) excitatory innervation in the esophagus muscle. In circular muscle segments, transmural application of brief electrical stimulation evoked two types of mechanical response: a biphasic response consisting of an initial relaxation and a following contraction (type I) and a contraction alone (type II). These mechanical responses were not modulated by either atropine or guanethidine. In the type I response, TTX abolished the relaxation component, suggesting that this was produced by non-adrenergic non-cholinergic (NANC) inhibitory nerve excitation. In about half of the type II responses, the amplitude of the contraction was significantly reduced by TTX, suggesting that a part of the contraction was produced by activation of NANC excitatory nerves. Thus, the esophageal smooth muscle of the frog demonstrates myogenic activity, and is innervated by both excitatory and inhibitory NANC nerves.

• 日本平滑筋学会の論文

著者

• Yoshida Masahide

  Laboratory Of Physiology Faculty Of Health And Social Work Kanagawa University Of Human Services

• YOSHIDA Masahide

  Laboratory of Biology, Kanagawa Prefectural College of Nursing and Medical Technology

関連論文

• Mechanical activity of frog esophagus muscle in response to electrical stimulation of intramural nerves
• A Light Microscope Study of the Distribution of Muscle in the Frog Esophagus and Stomach
• Studies on the Intramural Nerves of the Hamster and Mouse Gallbladders.
• Observation on the distribution of ganglia in the ganglionated plexus of guinea-pig gallbladder.
• Effect of aminoglycoside antibiotics on the electrical stimulation-induced contractile response of the guinea-pig ureter.

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