Quantification of Terbutaline in Pharmaceutical Formulation and Human Serum by Adsorptive Stripping Voltammetry at a Glassy Carbon Electrode

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The electrochemical oxidative behavior of terbutaline at the glassy carbon electrode was studied in a series of the Britton-Robinson buffer of pH 2-11. Cyclic and square-wave voltammograms of terbutaline at the pH values [<!-]9 exhibited a single irreversible anodic peak. A fully validated, simple, sensitive and precise square-wave adsorptive anodic stripping voltammetric procedure was described for the determination of terbutaline in bulk form, tablets and human serum. For 5×10^<-8>M bulk terbutaline a mean recovery of 98.78±0.94% (n=5) was achieved following its preconcentration by adsorptive accumulation onto the glassy carbon electrode at a +0.15V (vs. Ag/AgCl/KCl_s) for 180s. Limit of detection of 6×10^<-9>M and limit of quantitation of 2×10^<-8>M terbutaline were achieved in the bulk form or its formulations (Bricanyl[○!R] tablets). The described square-wave adsorption anodic stripping voltammetric procedure was successfully applied for the determination of terbutaline in human serum following medium exchange. Limit of detection of 1.41×10^<-8>M (3.173 ng ml^<-1>) and limit of quantitation of 4.70×10^<-8>M (10.575 ng ml^<-1>) were achieved in human serum with a mean recovery of 98.11±1.13%.
2007-07-01