HbAIの臨床的意義に関する研究 : とくに糖尿病病態を中心として

概要

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In this paper the clinical significance of HbAI level on diabetes mellitus was studied and the conclusion was summarized as follows ; 1) The modified column chromatographic method for the determination of HbAI was developed and this method was proved to be clinically useful tool. 2) Correlation between HbAI level and FBS levels was observed 3 to 4 week prior to blood sampling as well as glucose response to glucose tolerance test (O. GTT), while negative correlation between HbAI level and the peak resporise to O. GTT was found. 3) HbAI level was more elevated in old erythrocytes than in young erythrocytes and elevated in the medium with high concentration of glucose. 4) HbAI level was markedly more elevated in diabetics treated with insulin or oral hypoglycemic agents than diet control alone. 5) There was no significant difference between HbAI levels of juvenile onset -diabetes and maturity onset diabetes. 6) There was no correlation between HbAI and serum cholesterol or triglyceride level. 7) HbAI level was more elevated in diabetics with severe sequelae than without sequelae. 8) HbAI level was significantly elevated in patients with diabetic ketoacidosis. The in vitro study revealed that elevated HbAI level in diabetic ketoacidosis resulted from high glucose concentration in plasma as well as acidosis.
神戸大学の論文