Presence of a Cytoplasmic Retention Sequence within the Human Interleukin-1α Precursor(Immunology)
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概要
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Interleukin (IL)-1α is primarily translated as a 33 kDa molecule (IL-1α_<1-271>), and then processed into a 17 kDa molecule (IL-1α_<119-271>) by calpain. The precursor region of IL-1α (IL-1α_<1-118>) contains a nuclear localization signal (KVLKKRRL, residues 79-86). We investigated the intracellular localization of IL-1α fused with green fluorescent protein or β-galactosidase. IL-1α_<1-118> was localized exclusively in the nucleus, but IL-1α_<1-271> in both the nucleus and the cytoplasm, suggesting the presence of a cytoplasmic retention signal within the mature region of IL-1α. Furthermore, the intracellular localization of IL-1α with deletions from the C terminus, internal deletions and point mutations suggested that the cytoplasmic retention signal is located within residues 168-201.
- 社団法人日本動物学会の論文
- 2005-08-25
著者
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Watanabe Naoko
Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital
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KOBAYASHI Yoshiro
Department of Biomolecular Science, Faculty of Science, Toho University
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SUDO Makoto
Department of Pathology, Graduate School of Medicine, The University of Tokyo
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Watanabe Naoko
Department Of Biomolecular Science Faculty Of Science Toho University
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Sudo Makoto
Department Of Biomolecular Science Faculty Of Science Toho University
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Kobayashi Yoshiro
Department Of Biomolecular Science Faculty Of Science Toho University
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Kobayashi Yoshiro
Department Of Anesthesia National Hospital Organization Tokyo Medical Center
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