Prolactin, an Activator of Epithelial Na^+ Channel, Inhibits Basolateral K^+ Channels in Adult Tree Frog Skin(Physiology)
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概要
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Adult amphibian skin actively transports Na^+ from its apical to basolateral side while in turn, K^+ is recycled through Na^+, K^+-ATPase and K^+ channels located in the basolateral membrane. We previously found that PRL stimulates Na^+ transport in the skin of the adult tree frog (Hyla arborea japonica) via an increase in the open-channel density of the epithelial Na^+ channel (ENaC). If PRL also activates basolateral K^+ channels, this activation would help to stimulate Na^+ transport, too. Whether PRL does indeed stimulate basolateral K^+ channels in the adult tree frog was examined by measuring the short-circuit current across nystain-treated skin. Both tolbutamide, a K_<ATP> channel blocker, and tetrapentylammonium (TPA), a K_<Ca> channel blocker, blocked the current, the effect of TPA being more powerful than that of tolbutamide. Contrary to expectation, PRL inhibited the basolateral K^+ channels in this skin. In the presence of basolateral amiloride, PRL still inhibited the basolateral K^+ current, suggesting that the Na^+-H^+ exchanger located in the basolateral membrane does not mediate the inhibitory effect of PRL on the basolateral K^+ channels in Hyla.
- 社団法人日本動物学会の論文
- 2005-01-25
著者
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Takada Makoto
Department of Physiology and Department of Anatomy, Saitama Medical School
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Takada Makoto
Department Of Physiology Saitama Medical School
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