Enzymes and Catalysts. II. : Pig Liver Esterase-Catalyzed Asymmetric Synthesis of (-)- and (+)-Cucurbitine and Its (-)-Thio Analogue(Organic,Chemical)
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概要
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The asymmetric synthesis of (-)- and (+)-cucurbitine was carried out by a method involving 1,3-dipolar cycloaddition of the intermediary azomethine ylide and pig liver esterase (PLE)-catalyzed hydrolysis. The thio analogue, (-)-3-aminotetrahydrothiophene-3-carboxylic acid, was also synthesized.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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Achiwa Kazuo
Shizuoka College Of Pharmacy
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Morimoto Y
Josai Univ. Sakado Jpn
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MORIMOTO YOSHIHISA
Shizuoka College of Pharmacy