Promoting Effect of Pentamethylbenzene on the Deprotection of О-Benzyltyrosine and N^ε-Benzyloxycarbonyllysine with Trifluoroacetic Acid(Organic,Chemical)

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概要

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• О-Benzyltyrosine was rapidly deprotected without formation of 3-benzyltyrosine by treatment with trifluoroacetic acid containing pentamethylbenzene. This method was also found to be useful in the deprotection of N^ε-benzyloxycarbonyllysine [Lys(Z)] and N^G-4-methoxy-2,3,6-trimethylbenzenesulfonylarginine [Arg(Mtr)]. The new deprotecting method was successfully applied to the synthesis of kyotorphin (Tyr-Arg).

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• SAITO Isao

  Tsukuba Research Laboratories, Eisai Co., Ltd.,

• Tsuchiya Yutaka

  Tsukuba Research Laboratories Eisai Co. Ltd.

• Tsujii Masahiko

  Eisai Chemical Co. Ltd.

• YOSHINO HIROSIH

  Tsukuba Research Laboratories, Eisai Co., Ltd.

• Yoshino Hirosih

  Tsukuba Research Laboratories Eisai Co. Ltd.

• Saito Isao

  Tsukuba Research Laboratories Eisai Co. Ltd.

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• Promoting Effect of Pentamethylbenzene on the Deprotection of О-Benzyltyrosine and N^ε-Benzyloxycarbonyllysine with Trifluoroacetic Acid(Organic,Chemical)

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