Microbial Reduction of Naphthoxypropionic Acids(Organic,Chemical)

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概要

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• Racemic 2-(1-naphthoxy)propionic acid ((±)-1) and 2-(2-naphthoxy)propionic acid ((±)-4) were subjected to microbial reduction and simultaneous resolution with Glomerella cingulata(Mains and Primus strains), Gheospomim olivarum(G. olivarum) and Gloeosponum laeticohr(G. laeticolor), yielding (S)-(+)-2-(1-naphthoxy)propanol ((S)-2) and (R)-(+)-2-(2-naphthoxy)-propanol ((R)-5), and leaving (R)-(-)-2-(1-naphthoxy)propionic acid ((R)-1) and (S)-(-)-2-(2-naphthoxy)propionic acid ((S)-4), respectively. The optical purity of (S)-( +)-2-(1-naphthoxy)-propanol ((S)-2) reached 92% and over 99% ee when fermented with G. olivarum and Glomerella cingulata(Mains strain), respectively.

• 社団法人日本薬学会の論文
• 1987-06-25

著者

• 津田 貴子

  Faculty Of Pharmaceutical Sciences Hoshi University

関連論文

• Microbial Reduction of Naphthoxypropionic Acids(Organic,Chemical)
• Microbial Reduction of 2-Phenylpropionic Acid, 2-Benzyloxypropionic Acid and 2-(2-Furfuryl) propionic Acid
• Microbial Reduction and Resolution of Herbicidal 2-Alkyl-2-aryloxyacetic Acids by Gloeosporium olivarum
• Syntheses of Antifungal Isocoumarins. III. Synthesis and Antifungal Activity of 3-Aryl-3,4-dihydro-4-substituted-isocoumarins
• Antifungal Activity of Oosponol, Oospolactone, Phyllodulcin, Hydrangenol, and Some Other Related Compounds
• Syntheses of Antifungal Isocoumarins. II. Synthesis and Antifungal Activity of 3-Substituted Isocoumarins

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