Two-Dimensional Nuclear Magnetic Resonance Spectra of Selected Tricyclic Antidepressants(Organic,Chemical)

概要

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Two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy has been used to assign ^<13>C spectra of the tricyclic antidepressants imipramine and chlorimipramine. The 2D-INADEQUATE method was used to unambiguously assign the aromatic spectral region for the former compound. Errors in previous literature assignments based on 1D methods were corrccted. For chlorimipramine the pitfalls of classical substituent chemical shift arguments for ^<13>C assignments and the difficulties of 1D selective ^1H irradiation in overlapped systems are contrasted with the power and relative simplicity of the 2D-^<13>C, ^1H-correlated and ^<13>C, ^1H RELAY methods.
公益社団法人日本薬学会の論文
1987-01-25