Platelet-Activating Factor (PAF) Receptor Binding Antagonist Activity of the Methanol Extracts and Isolated Flavonoids from Chromolaena odorata (L.) KING and ROBINSON(Pharmacognosy)

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The leaf, stem and root extracts of Chromolaena odorata were evaluated for their effect on platelet-activating factor (PAF) receptor binding on rabbit platelets using ^^3H-PAF as a ligand. The leaf extract demonstrated high PAF receptor binding inhibitory activity of 79.2±2.1% at 18.2μg/ml. A total of eleven flavonoids were subsequently isolated from the active leaf extract and evaluated for their effects on PAF receptor binding. Eight of the flavonoids exhibited >50% inhibition on the binding activity at 18.2μg/ml. These flavonoids were identified as eriodictyol 7,4'-dimethyl ether, quercetin 7,4'-methyl ether, naringenin 4'-methyl ether, kaempferol 4'-methyl ether, kaempferol 3-O-rutinoside, taxifolin 4'-methyl ether, taxifolin 7-methyl ether and quercetin 4'-methyl ether. Their IC_<50> values ranged from 19.5 to 62.1μM.
公益社団法人日本薬学会の論文
2007-06-01