癌臨床応用をめざすドラッグデリバリーシステム

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The application of a Span vesicle, mainly composed of non-ionic surfactant Span80, to drug delivery system for a cancer therapy was investigated. Euchuma Serra agglutinin (ESA), which was a new lecthin and was obtained by ethanol extraction from marine alga, specifically combined with a sugar chain of high mannose type of cancer cells (especially strong with colon cancer cell) and inhibited the growth of the colon cancer cell. Span vesicle on whあich ESA was immobilized together with polyetyleneglycole (PEG) for the protection from the macrophage attack was newly prepared (abbreviated as EPV). In the intravenous injection of the experimental conditions that [ESA] = 0.25mg/vesicle(ml); injection volume of vesicle suspension = 0.2ml; at 9th day after the first injection, the administration of EPV to BALB/c nude mouse with tumor of human colon cancer decreased in the reference growth of the mouse tumor down to about 48%. Moreover, the EPV was applied as a microcapsule-carrier by encapsulating an anti-tumor drug TXT, having the targeting function to the colon-cancer tumor (abbreviated as ETPV). The intravenous injection of ETPV under the above conditions ([TXT] = 0.7mg/vesicle(ml)) also decreased in the growth of the mouse tumor down to about 25% and also reduced the side effect from the TXT (the mouse weight increased), compared with the case of free-TXT injection. Thus, we demonstrated the application of EPV, not using anti-cancer drug and also proposed the application of EPV as a drug microcapsule for the cancer therapy to reduce the drug side-effect.

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