舌癌治療モデルの確立とその応用に関する実験的研究
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概要
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With the purpose of establishing an experimental therapeutic model of lingual carcinoma effectively, variations were detected with concentration and solvents of DMBA (9, 10-dimetyl, 1, 2 benzanthracene) and periods of carcinogenic treatment. 1.0% DMBA acetone solution was more effective to bring about lingual carcinoma in hamsters than 0.5% DMBA acetone or 0.5% DMBA benzen. The most effective method to bring about lingual carcinoma is summarized as follows ; Golden syrian hamsters at age approx. 2 months were subjected to staining of 1.0% DMBA acetone solutuion with traumatic irritations, repeated 3 times a week for 11 succesive weeks, and kept intact for a subsequent 4 weeks. Carcinogenicity rate of this group was 81.6% and tumor of this group showed a tendency to exophitic proliferation. As for applications of FT207(1-2-tetrahydrofuryl-5fluorouracil) to this experimental model, hamsters were divided into 4 groups with a difference in phases and intervals of FT207 administrations. Only the group administered 100mg/kg 6 times a week from the 12th week up until the 15th week, demonstrated significant lower carcinogenicity and T/C. In other groups recieving the same dose but with different phases and intervals there were no significant differences against contrpl group. In order to analyze these facts, the concentration of 5FU (5-fluorouracil) in glossal tissues following i.p. administration of FT207 100 mg/kg was evaluated by bioassay method, and the immunization capacity of hamsters, such as the number of PFC and DNCB dermal reaction test, was conducted. Thus, it was noted that FT207 strongly inhibits the humoral immunization in this experimental model, but shows hardly any effects upon the cellular immunization. It was conjectured that differences in the inhibitory effect against carcinogenicity by administration of FT207 would mainly be attributable to the differences in the duration of local concentrations of5FU, which are due to the varying intervals of its administration.
- 神戸大学の論文