α-Tocopherolによるアルコール性脂肪肝の抑制治療実験とその作用機序に関する研究
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概要
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The inhibitory mechanism on ethanol-induced fatty liver was investigated. α-Tocopherol 100 mg/kg body weight was intraperitoneally inject~d with the commencement of ethanol administration on 5 weeks successively. As the mechanism of occurrence of ethanol-induced fatty liver in normal rat, triglyceride overproduction in the liver, disturbance of VLDL-TG release from liver due to the trouble of lipoprotein formation in liver, and the disturbance of oxidation of fatty acid were revealed. On the other hand, as the mechanism of occurrence of fatty liver in diabetic rat, increase of triglyceride synthesis in liver plays a main role, and, in addition, decrease of VLDL-TG releasing capacity from liver and disturbance of fatty acid oxidation have been suggested. Through simultaneous administration of α-tocopherol, inhibition of ethanol-induced fatty liver was observed in the normal and diabetic rats. In the fatty liver in the former, lipid peroxide was increased in the mitochondria and microsome fractions, in the latter it was increased in the microsome fraction, these were decreased through α-tocopherol administration and the fatty liver was inhibited simultaneously. As the mechanism of inhibition of ethanol-induced fatty liver by a-tocopherol, slight inhibition of triglyceride synthesis, slight increase of VLDL-TG release from liver and improvement in the disturbance of fatty acid oxidation were considered in normal rat. On the other hand, in diabetic rat also the above similar results were obtained. Concerning the occurrence of ethanol-induced fatty liver and inhibition by a-tocopherol, the increase or decrease of lipid peroxide in liver microsome or mitochondria fraction was considered to play an important role.
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