The Extract of Gynostemma pentaphyllum Enhanced the Production of Antibodies and Cytokines in Mice
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概要
- 論文の詳細を見る
Gynostemma pentaphyllum is a popular herbal tea in China and some Asian countries. The modulatory function of G. pentaphyllum total plant extracts on immune cells was evaluated in this study. The extract was intraperitoneally injected into mice for 5 consecutive days. The production of antibodies from B cells or cytokines from T cells was determined mainly with ELISA. After the treatment, serum IgM and IgG2a were significantly enhanced and showed dosedependent effect. Moreover, serum IgA and IgG1 were also increased when received the extract at the doses of 0.05 or 0.50 g/kg/day. In addition to the serum levels, the injection of the extract enhanced the production of all antibodies from LPS-activated spleen cells. Furthermore, more cytokines were secreted from Con A-stimulated splenocytes of G. pentaphyllum-treated mice. Our results suggest that the extract of G. pentaphyllum might promote immune responses through the activation of T and B cells.
- 2007-05-01
著者
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Yang Rong-chi
Department Of Chinese Herbal Pharmacy Chang Gung Memorial Hospital
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Huang Wen-chung
The Department Of Life Science National Taiwan Normal University:chang Gung Institute Of Technology
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KUO Ming-Ling
Department of Microbiology and Immunology, Graduate Institute of Basic Medical Science, Chang Gung U
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LI Ming-Liang
The Department of Life Science, National Taiwan Normal University
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LIOU Chian-Jiun
Chang Gung Institute of Technology
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SHEN Jiann-Jong
School of Traditional Chinese Medicine, Chang Gung University
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Kuo Ming-ling
Department Of Microbiology And Immunology Graduate Institute Of Basic Medical Science Chang Gung Uni
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Li Ming-liang
The Department Of Life Science National Taiwan Normal University
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Shen Jiann-jong
School Of Traditional Chinese Medicine Chang Gung University