Plasma Level of Mitochondrial Coupling Factor 6 Increases in Patients With Coronary Heart Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background The aim of the present study was to investigate alterations in the plasma level of coupling factor 6 (CF6), a novel endogenous inhibitor of prostacyclin, in patients with coronary heart disease. Methods and Results In total, 35 patients with coronary heart disease and 20 age-matched healthy subjects were examined. Plasma levels of CF6 and 6-keto-prostaglandin (PG) Fia (a stable metabolite of prostacyclin) were measured using radioimmunoassay. The plasma level of CF6 was significantly increased in patients (254.1± 29.8pg/ml vs 219.4±36.7pg/ml in controls, p<0.0001), whereas that of 6-keto-PGFia was significantly decreased (23.4±2.3pg/ml vs 26.1±4.5pg/ml in controls, p=0.001). Moreover, after percutaneous transluminal coronary angioplasty (PTCA) and stent therapy, the level of CF6 was further increased by 30% to 330.4±26.0pg/ml, and that of 6-keto-PGFia was decreased by 42% to 13.5±2.0pg/ml, compared with baseline (all p<0.01). Univariate analysis showed a significant result that the plasma level of CF6 was inversely correlated with that of 6-keto-PGFia in the patients. The plasma ratio of CF6 to 6-keto-PGFia was 8.4 in the control group and that in patients with coronary heart disease was increased to 24.4 after the therapy from 10.9 before therapy. Conclusions The results suggest that an increased CF6 level may be responsible in part for the decreased prostacyclin level observed in patients with coronary heart disease, in particular after PTCA and stent therapy. As a potential risk factor for coronary heart disease, CF6 might have important clinical significance.
- 社団法人日本循環器学会の論文
- 2007-04-20
著者
-
LI Xue
Department of Medical Genetics, Tohoku University School of Medicine
-
Li Xue
Department Of Ophthalmology Eye Center Of Beijing University
-
Li Xue
Department Of Medical Genetics Tohoku University School Of Medicine
-
Tang Chao
Department Of Physiology And Pathophysiology Peking University Health Science Center
-
Chai San
Department of Cardiovascular Disease, Beijing Fengtai Hospital
-
Hui Yong
Department of Cardiovascular Disease, Beijing Fengtai Hospital
-
Hui Yong
Department Of Cardiovascular Disease Beijing Fengtai Hospital
-
Chai San
Department Of Cardiovascular Disease Beijing Fengtai Hospital
-
Li Xue
Department of Cardiology, the Fourth Hospital of Harbin Medical University
関連論文
- Haplotype analysis suggests that the two predominant mutations in Japanese patients with holocarboxylase synthetase deficiency are founder mutations
- Plasma Mitochondrial Coupling Factor 6 in Patients with Acute Myocardial Infarction
- Plasma Level of Mitochondrial Coupling Factor 6 Increases in Patients With Coronary Heart Disease
- High-Temperature Complex Refractive Index of Phase Change Recording Medium of Ge2Sb2Te5 Determined Using Phase Change Static Tester and Spectroscopic Ellipsometer
- Enhanced Readout Signal of Elliptic-Bubble Super Resolution Near Field Structure by Temperature-Dependent Complex Refractive Index of Phase-Change Medium
- Retraction of: Loading Effect of 200 mg Cilostazol on Platelet Inhibition in Patients Undergoing Percutaneous Coronary Intervention
- Aggregation of pre-implantation embryos improves establishment of parthenogenetic stem cells and expression of imprinted genes