Release of Drugs from Liposomes Varies with Particle Size(Biopharmacy)
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概要
- 論文の詳細を見る
The efficacy of many drugs is improved by liposomal formulations. The greatest improvements in therapeutic benefits are achieved if the drug is retained in the liposomes for several hours after administration. Many basic drugs can be concentrated efficiently into liposomes in response to a transmembrane pH gradient. However, the rate of release from liposomal formulations is drug-dependent; for example, doxorubicin is released slowly from liposomes whereas vincristine leaks out rapidly. The aim of this study was to identify the causes of the rapid release of drugs from liposomes and then to apply this knowledge to the development of more stable formulations. Our initial focus was to explore the influence of liposomal size on the rate of release of drugs. The retention of doxorubicin within liposomes was independent of the particle size as far as this experimental condition was concerned. However, the rate of release of vincristine varied in relation to the particle size of the liposomes; vincristine was retained more effectively in larger liposomes. Experimental data generated using ^<31>P-NMR analysis and trap volume measurements, indicated that the number of lipid bilayers in liposomes increased as the particle size was increased. Additional lipid bilayers are likely to present a more effective barrier thereby slowing the release of drugs.
- 公益社団法人日本薬学会の論文
- 2007-05-01
著者
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Abe Masayuki
Departments Of Pharmacokinetics And Pharmacodynamics Pharmacognosy And Global Center Of Excellence (
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YAMAUCHI Masahiro
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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NAKAKURA Masashi
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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Abe Masayuki
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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TSUTSUMI Kyoko
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co.. Ltd.
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UOSAKI Yoichi
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co.. Ltd.
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AOKI Noburu
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co.. Ltd.
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Aoki Noburu
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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Uosaki Yoichi
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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Tsutsumi Kyoko
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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Yamauchi Masahiro
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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Nakakura Masashi
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co.. Ltd.
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Yamauchi Masahiro
Drug Formulation Research Laboratories Pharmaceutical Research Center Kyowa Hakko Kogyo Co. Ltd.
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Nakakura Masashi
Drug Formulation Res. Laboratories Pharmaceutical Res. Center Kyowa Hakko Kogyo Co. Ltd.
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