哺乳類ヘモグロビンの協同作用とボーア効果は協調して酸素の獲得と輸送を行っている : 規範タンパク質における新たな視点

概要

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The slope of the oxygen equilibrium curve (OEC) of mammalian-hemoglobin (Hb) is maximized at S (oxygen saturation) value of 0.38, and the slope of the S vs. P/P_<50> (P is partial oxygen pressure; P_<50> is P at S = 1/2) plot at a P/P_<50> value of 1 is one-forth that of the Hill-co-efficient (n). OECs of mammalian Hbs are designed to have an identical optimal P_<50> value for O_2 delivery and the effectiveness of the Bohr shift (shift of OEC upon pH changes) at O_2 loading site. This fact is favorable for uptake and delivery of maximum amount of O_2 for fetal blood. To have the identical optimal P_<50> Value for O_2 delivery and for the efficiency of the Bohr shift, the relationship, PaO_2/ PvO_2 = ((n + 1)/(n - 1))^<2/n>, is required to hold, where PaO_2 and PvO_2 are P for arterial and venous bloods, respectively.
2007-05-25