Mutagenic Activity of Atmospheric Ultrafine Particles at a Roadside Site and a Suburban Site
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概要
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The mutagenic activity of size-fractionated atmospheric participate matter (PM) was investigated at both a roadside site and a suburban site in Saitama, Japan. Sampling was carried out using a low-pressure cascade impactor between January and February 2005. The mutagenic activity of the size-fractionated PM was determined by the Ames test using Salmonella typhimurium strain TA98 without metabolic activation (S9). Most of the mutagenic activity was found in the fine particle fraction (< 2.1 μm) at both sites. There was almost no difference in the contribution of fine particles to the mutagenic activity of total PM between the two sites. On the other hand, there was a clear difference in the contribution of ultrafine particles (< 0.12 μm) to the mutagenic activity between the two sites. At the suburban site, ultrafine particles accounted for 5.7% of the mutagenic activity of total PM. In contrast, at the roadside site, ultrafine particles contributed as much as 12% to the mutagenic activity of total PM, although their contribution to the total PM mass was only 2.3%. Moreover, the mutagenic activity per unit air volume in the ultrafine particle fraction at the roadside site (1.2 revertants/m^3) was 3.1-fold higher than that at the suburban site (0.38 revertants/m^3), although the activity in the fine particle fraction at the roadside site was only 1.4-fold higher than that at the suburban site. These results indicated that, with regard to mutagenicity, the health risk due to ultrafine particles is relatively high at roadside areas.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
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Sakamoto Kazuhiko
Department of Environmental Science and Technology, Graduate School of Science and Engineering, Sait
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Sakamoto Kazuhiko
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Yun Sun-ja
The Institute Of Basic Environmental Research Environmental Control Center Co. Ltd.
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Kawanaka Youhei
The Institute of Basic Environmental Research, Environmental Control Center Co., Ltd.
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Matsumoto Emiko
The Institute of Basic Environmental Research, Environmental Control Center Co., Ltd.
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Wang Ning
The Institute of Basic Environmental Research, Environmental Control Center Co., Ltd.
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Tsuchiya Yoshiteru
The Institute of Basic Environmental Research, Environmental Control Center Co., Ltd.
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Jiang Zhao
Department of Environmental Science and Human Engineering, Graduate School of Science and Engineerin
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Jiang Zhao
Department Of Environmental Science And Human Engineering Graduate School Of Science And Engineering
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Sakamoto Kazuhiko
Dep. Of Environmental Sci. And Technol. Graduate School Of Sci. And Engineering Saitama Univ.
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Matsumoto Emiko
The Institute Of Basic Environmental Research Environmental Control Center Co. Ltd.
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Kawanaka Youhei
The Institute Of Basic Environmental Research Environmental Control Center Co. Ltd.:department Of En
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Tsuchiya Yoshiteru
The Inst. Of Basic Environmental Res. Environmental Control Center Co. Ltd.
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Tsuchiya Yoshiteru
The Institute Of Basic Environmental Research Environmental Control Center Co. Ltd.
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Sakamoto Kazuhiko
Department Of Applied Chemistry Faculty Of Engineering Saitama Universtiy
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Wang Ning
The Institute Of Basic Environmental Research Environmental Control Center Co. Ltd.
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