Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats
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概要
- 論文の詳細を見る
The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats. Oral administration of ethanolic extract of the fruits (200 mg/kg body weight/rat/day) for 30 days significantly reduced the levels of blood glucose and glycosylated hemoglobin in diabetic rats. Determination of plasma insulin levels revealed the insulin stimulating action of the fruit extract. Also, the alterations observed in the activities of carbohydrate and glycogen metabolising enzymes were reverted back to near normal after 30 days of treatment with the extract. Electron microscopic studies showed significant morphological changes in the mitochondria and endoplasmic reticulum of pancreatic β cells of STZ-induced diabetic rats. Also, a decrease in the number of secretory granules of β-cells was observed in the STZ-induced diabetic rats and a these pathological abnormalities were normalized after treatment with T. chebula extract. The efficacy of the fruit extract was comparable with glibenclamide, a well known hypoglycemic drug.
- 公益社団法人日本薬学会の論文
- 2006-06-01
著者
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Senthil Kumar
Department Of Biochemistry And Molecular Biology University Of Madras Guindy Campus
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Senthil Kumar
Department Of Analytical Chemistry School Of Chemical Sciences University Of Madras
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Sathish Kumar
Department Of Biochemistry And Molecular Biology University Of Madras Guindy Campus
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Arulselvan Palanisamy
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus
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Subramanian Sorimuthu
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus
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Arulselvan Palanisamy
Department Of Biochemistry And Molecular Biology University Of Madras Guindy Campus
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Subramanian Sorimuthu
Department Of Biochemistry And Molecular Biology University Of Madras Guindy Campus
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