Morphology, Function, and Differentiation of Bone Cells
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概要
- 論文の詳細を見る
Bone plays a pivotal role in storing calcium and phosphate in vertebrates. This tissue is maintained by the balance of bone formation and bone resorption. Osteoblast-lineage cells, consisting of osteoblasts, osteocytes and bone lining cells, are engaged in bone formation. Bone resorption is mediated by osteoclasts. Recent research revealed that receptor activator of NF-KB (RANK)-RANK ligand (RANKL) mechanism is essential for the differentiating and activating osteoclasts. Osteoblast-lineage cells regulate bone resorption via the expression of RANKL and osteoprotegerin (OPG), a decoy receptor for RANKL. Additionally, osteoblast-lineage cells participate in degradation of bone matrix by secreting MMP-13. Thus, bone remodeling is achieved by the harmonized orchestration of osteoblast-lineage cells and osteoclast-lineage cells.
- 硬組織再生生物学会の論文
著者
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Nakamura Hiroaki
Department Of Oral Histology Matsumoto Dental University
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Nakamura Hiroaki
Department Of Anatomy Faculty Of Medicine Saitama Medical University
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