Electrochemical Determination of Meloxicam in Pharmaceutical Preparation and Biological Fluids Using Oxidized Glassy Carbon Electrodes
スポンサーリンク
概要
- 論文の詳細を見る
The adsorptive and electrochemical behaviors of meloxicam (MLC) was investigated on a glassy carbon electrode that was electrochemically treated by anodic oxidation at +1.8V, following potential cycling in the potential range from -0.8 to 1.0 V vs. Ag/AgCl reference electrode. The resulting electrode showed a good activity to improve the electrochemical response of the drug. MLC was accumulated at an electrochemically activated glassy carbon electrode (phosphate buffer pH 6) in a certain time and then determined by linear sweep voltammetry. The oxidative peak currents showed a linear function in the concentration ranges of 0.02 to 10μм using a 240 s preconcentration time. The preconcentration medium-exchange approach was utilized for the selective determination of the drug in spiked urine and plasma samples with satisfactory results. The recovery values of the proposed method obtained 105% (RSD 2.5%) and 100% (RSD 1.8%) for urine and plasma samples, respectively. Also, the proposed method has been successfully used for determination of MLC in tablets.
- 2007-04-01
著者
-
Farhadi Khalil
Department Of Chemistry Faculty Of Science Urmia University
-
KARIMPOUR Ahmad
Department of Chemistry, Faculty of Science, Urmia University
-
Karimpour Ahmad
Department Of Chemistry Faculty Of Science Urmia University
関連論文
- Electrochemical Determination of Meloxicam in Pharmaceutical Preparation and Biological Fluids Using Oxidized Glassy Carbon Electrodes
- Headspace Solid-Phase Microextraction-Gas Chromatography Method for the Determination of Valproic Acid in Human Serum, and Formulations Using Hollow-Fiber Coated Wire
- [Tetrakis(4-N, N-dimethylaminobenzene)porphyrinato]-manganese(III) Acetate as a Novel Carrier for a Selective Iodide PVC Membrane Electrode
- Separation Study of Cadmium as CdI_4^ through a Bulk Liquid Membrane Containing Ketoconazole and Oleic Acid
- Analysis of Ethanol and Methanol in Human Body Fluids by Headspace Solid Phase Microextraction Coupled with Capillary Gas Chromatography
- Clotrimazole-Triiodide Ion Association as an Ion Exchanger for a Triiodide Ion-Selective Electrode
- Electrochemical Behavior and Determination of Clozapine on a Glassy Carbon Electrode Modified by Electrochemical Oxidation