Poly(Lactic-co-glycolic Acid) Microspheres for the Controlled Release of Huperzine A : In Vitro and in Vivo Studies and the Application in the Treatment of the Impaired Memory of Mice
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概要
- 論文の詳細を見る
Huperzine A loaded poly (D, L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by an oil/water (o/w) solvent evaporation technique. With a decrease of the ratio of o/w from 1 : 100 to 1 : 50, the encapsulation efficiency was reduced about 4%. Increasing the PVA concentration from 0.5 to 2% reduced the percentage encapsulation efficiency of huperzine A from 60.7 to 47.4% and the particle size of microspheres from 84.2 to 26.2μm. The addition of stearic acid improved the encapsulation efficiency, but also accelerated the in vitro release of hupezine A from microspheres. After i.m. administration of huperzine A loaded microspheres in mice, huperzine A was sustained released from the PLGA microspheres up to 12 d with a low initial burst. Passive avoidance test of mice showed that the microspheres formulation offered an improved therapeutic efficiency in the treatment of the impaired memory of the mice superior to injection gastric (i.g.) administration of huperzine A suspension at the same dose, whose therapeutic efficiency was similar as that of a 50% reduced dose of the microspheres formulation.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Liu Wanhui
School Of Pharmacy Yantai University:research And Development Center Shandong Luye Pharmaceutical Co
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Liu Wanhui
School Of Pharmacy Yantai University
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CHU Dafeng
College of Life Science, Jilin University
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TIAN Jingwei
School of Pharmacy, Yantai University
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LI Zi
School of Pharmacy, Yantai University
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LI Youxin
College of Life Science, Jilin University
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Tian Jingwei
School Of Pharmacy Yantai University:research And Development Center Shandong Luye Pharmaceutical Co
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Li Youxin
College Of Life Science Jilin University:school Of Pharmacy Yantai University
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Li Zi
School Of Pharmacy Yantai University
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Chu Dafeng
College Of Life Science Jilin University:school Of Pharmacy Yantai University
関連論文
- Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma
- Poly(Lactic-co-glycolic Acid) Microspheres for the Controlled Release of Huperzine A : In Vitro and in Vivo Studies and the Application in the Treatment of the Impaired Memory of Mice
- High-performance liquid chromatography spectrometric analysis of tripterin in rat plasma
- Effects of Formulation Parameters on Encapsulation Efficiency and Release Behavior of Risperidone Poly(D,L-lactide-co-glycolide) Microsphere