Microbial Transformation of 5-Episinuleptolide
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概要
- 論文の詳細を見る
5-Episinuleptolide (1) is an abundant norcembranolide diterpene isolated from several species of the soft coral genus Sinularia. Biocatalytic transformation studies of 1 using Streptomyces lavendulea ATCC 8664 resulted in the isolation and characterization of two new metabolites 2 and 3. Compound 2, 6α-hydroxy-5-episinuleptolide was produced via a stereoselective reduction of 1 and was further metabolized into compound 3 which has a 3, 8-bicylized cembranoid skeleton. The structures and configurations of the metabolites were determined by spectroscopic and X-ray crystallographic analyses.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Khalifa Sherief
Dep. Of Pharmacognosy Fac. Of Pharmacy Suez Canal Univ.
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Khalifa Sherief
Department Of Pharmacognosy Faculty Of Pharmacy Suez Canal University
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Fronczek Frank
Department Of Chemistry Louisiana State University
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KAMEL Haidy
Department of Pharmacognosy and National Center for Natural Products Research, RIPS, School of Pharm
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SLATTERY Marc
Department of Pharmacognosy and National Center for Natural Products Research, RIPS, School of Pharm
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Kamel Haidy
Department Of Pharmacognosy And National Center For Natural Products Research Rips School Of Pharmac
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Slattery Marc
Department Of Pharmacognosy And National Center For Natural Products Research Rips School Of Pharmac
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