遺伝性高脂血症ウサギ(WHHL-rabbit)における動脈硬化性病変に及ぼす高酸素ならびに低酸素吸入の影響
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概要
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The present study was undertaken in order to elucidate the effects of systemic hyperoxia and hypoxia on plasma lipids and atherogenesis in WHHL-rabbits which show marked hypercholesterolemia and hypertriglyceridemia from birth. Of 15 male WHHL-rabbits (2-3 months of age), 6 rabbits were exposed to 40% oxygen (hyperoxic) and 5 were exposed to 10% oxygen (hypoxic) for 5 hours daily on 5 days of each week for 8 weeks. Four rabbits without such exposure were used as controls. The results obtained were as follows : 1) The ratio of the area of sudanophilic lesion to the total intimal area of the aorta were lower in the hyperoxic rabbits, and higher in the hypoxic rabbits than in the controls. The difference between the hyperoxic and hypoxic groups was significant. 2) The level of plasma cholesterol was not affected significantly by the hyperoxic or hypoxic exposure throughout the experimental period. Therefore, the average plasma cholesterol levels in three groups indicated almost the same value. 3) The levels of plasma triglycerides increased significantly by systemic hypoxia but were not affected by hyperoxia, and the average plasma triglyceride values were not higher in the hypoxic rabbits than in the hyperoxic or comol animals. 4) There were no significant correlations between the extent of the aortic lesions and the levels of plasma cholesterol or triglycerides. From these results, it is postulated that the progress of atherosclerotic changes of the aorta is Suppressed or promoted by systemic hyperoxia or hypoxia, respectively, not through the changes in the plasma lipid levels, but through the direct effects on the aortic wall. The possible role of hypoxia playing in atherogenesis was discussed.
- 神戸大学の論文