Secondary Metabolites from Andrographis paniculata
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概要
- 論文の詳細を見る
Two new flavonoid glycosides, 5-hydroxy-7, 8-dimethoxy (2R)-flavanone-5-0-β-D-glucopyranoside (1) and 5-hydroxy-7, 8, 2', 5'-tetramethoxy-flavone-5-0-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11, 12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED_<50> values of 6.5 and 5.1μg/ml, respectively.
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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Zhang Hongjie
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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Zhang Hongjie
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Van Breemen
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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Li Wenkui
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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Li Wenkui
Department Of Bioanalytical Chemistry Covance Laboratories Inc.
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Fong Harry
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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XU Xudong
Department of Medicinal Chemistry and Pharmacognosy (m-c 781), University of Illinois at Chicago
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MA Cuiying
Department of Medicinal Chemistry and Pharmacognosy (m-c 781), University of Illinois at Chicago
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FITZLOFF John
Department of Medicinal Chemistry and Pharmacognosy (m-c 781), University of Illinois at Chicago
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Xu Xudong
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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Fitzloff John
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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Ma Cuiying
Department Of Medicinal Chemistry And Pharmacognosy (m-c 781) University Of Illinois At Chicago:prog
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- Secondary Metabolites from Andrographis paniculata
- Secondary Metabolites from Andrographis paniculata