軽度慢性膵障害時の膵内外分泌ならびにエネルギー代謝に関する実験的検討
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the pathologic physiology in the early stage of chronic pencreatitis, the changes and relationships between pancreatic endo- and exocrine functions, and the effects on the liver were studied. in relation to energy metabolism, using a model of chronic pancreatic disorder, caused to be slight fibrosis by ligating the main pancreatic duct of dogs. In the study of pancreatic exocrine function, the content of amylase in the pancreatic tissue tended to decrease from the early stage, and the decrease of pancreatic exocrine function at a subclinical level seemed to be present from the early period. In the study of pancreatic endocrine function, the value of blood sugar showed no difference between the control and ligated groups, irrespective of glucose loading, but the function of IRI secretion at ivGTT showed an excessive secretory reaction in the course of time, with maintained high value. The activity of pancreatic glycolytic enzymes showed a tendency of increase in glucokinase and hexokinase activities 2 weeks and 2 months after ligation of the main pancreatic duct. The pancreatic phosphofructokinase activity also showed an increase with time. In the activity of hepatic glycolytic enzymes, however, the hepatic phosphofructokinase activity showed a gradual decrease. From the above, it suggested that a reasonable defense reaction might be occuring to promote the pancreatic endocrine function and pancreatic energy metabolism to prevent the decrease of pancreatic function in the early stage of chronic pancreatitis.
- 神戸大学の論文