歯周疾患患者歯肉における遊走活性因子について

概要

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The chemotactic factors in the inflamed gingival tissues from severe periodontal patients were identified by the biochemical analysis. Degree of contribution to chemotactic activity of each factor identified in each case was determined by removing one of chemotactic factors and by blocking receptor of cell surface. The results were as follows: 1) High chemotactic activities to PMN's and macrophages were found in the gingival tissues from severe periodontal patients as compared with clinically healthy tissues. 2) Chemotactic factors were separated from gingival tissues with high chemotactic activities and were analyzed, and it was found that chemotactic activities were generated by IgG-derived factor and by collagen degradation products. 3) As a result of identifing chemotactic factor in each case, high chemotactic activities were found in the factors derived from immunogloblin, bacteria and collagen degradation products, but it wasn't uniform.
特定非営利活動法人日本歯周病学会の論文
1982-09-28