ラットにおけるジフェニルヒダントイン性歯齦増殖症に関する実験病理組織学的研究 : 特に炎症がジフェニルヒダントイン性歯齦増殖症に及ぼす影響について

概要

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The purpose of this study was to clarify the incidental mechanism of diphenylhydantoin (DPH) gingival hyperplasia, especially the role of gingival inflammation in diphenylhydantoin gingival hyperplasia. As the experimental animals, 90 wister-strain male rats were used. They were divided four groups. Experimental rats in Group A were used as a non-treated control. Experimental rats in Group B were given an intraabdominal administration of DPH. Small cavities were prepared for the maxillar molars in eachrat of Group C and Group D so as to induce chronic inflammatory changes for gingiva by the dental plaque. Experimental rats in Group B and Group D were administered DPH for 7 days, 14 days, 28 days, 56 days and 84 days respectively. These experimental rats were examined macroscopically and histologically. It was possible to reproduce the macroscopical and historogical appearance of DPH gingival hyperplasia in rats receiving DPH and accumulating of no dental plaque didn't obvious gingival hyperplasia. Analysis of these results reveals that inflammation of gingiva was considered to be one of the causative factors of DPH gingival hyperplasia.
特定非営利活動法人日本歯周病学会の論文
1982-09-28