イヌの実験的歯肉炎に関する免疫病理学的研究 : 第2報歯肉炎発生と免疫複合体について

概要

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The deposition of immune complexes was investigated in various stages of experimental gingivitis by immunofluorescence. After the bimaxillary premolars of beagle dogs were brushed for 1 month to obtain a clinically healthy gingiva, the experimental gingivitis was induced by plaque accumulation following ligature with floss silk. The gingival biopsy specimens were obtained at 0 day, 1 week, 1 month and 3 months after the start of plaque accumulation. The localization of immunoglobulins (Ig), complement (C3) and antiplaque antibody (Ab) was compared in these specimens, untreated and treated with PBS or citrate buffer using immunofluorescent antibody and antigen techniques. The following findings were obtained: The localization of C3 increased with times to the maximum level 1 month postoperatively, resulting in a plateau at 3 month postoperative periods and IgM and Ab localized in a similar fashion. Therefore this finding reflects a presence of immune complexes. However, since a large majority of Ig, C3 and Ab localized in early and established lesions were washed out with PBS, not indicating that the immune complexes deposited in a tightly fixed state.
特定非営利活動法人日本歯周病学会の論文
1981-12-28